VSOP - MRT-Kontrastmittel auf Eisenoxid-Nanopartikel Basis

MRI contrast agents based on iron-nanoparticles



Publikationen und Patente /
Publications and patents


    • Relevant Nanoparticle Patents
      Nanoparticle Patents

      1. BISMUTH-IRON OXIDE CONTRAST AGENTS; Publication info: US2016271275 (A1) 2016-09-22
      2. Black phosphorus-graphene composite nanometer contrast agent and preparation hereof, and application of contrast agent to acupuncture research; Publication info: CN105944114 (A) 2016-09-21
      3. Super-paramagnetic iron oxide nanoparticle compound as well as preparation method and application thereof; Publication info: CN105412951 (A) 2016-03-23
      4. Preparation method of RGD polypeptide targeted zinc-doped ferriferrous oxide nanoparticle; Publication info: CN105412949 (A) 2016-03-23
      5. Kit for tracing uterus implanting stem cell prognosis, and preparation method thereof; Publication info: CN105368774 (A) 2016-03-02
      6. Metal Oxide Nanoparticle-Based Magnetic Resonance Imaging Contrast Agent with a Central Cavity; Publication info: US2016051708 (A1) 2016-02-25
      7. Metal Oxide Nanoparticle-Based T1-T2 Dual-Mode Magnetic Resonance Imaging Contrast Agent; Publication info: US2016051707 (A1) 2016-02-25
      8. Superparamagnetic iron oxide nano MRI (magnetic resonance imaging) probe and preparation method and application thereof; Publication info: CN105267992 (A) 2016-01-27
      9. Zinc oxide-gadolinium-drug composite nanoparticle, and preparation method and application thereof; Publication info: CN105126125 (A) 2015-12-09
      10. Nanoparticles For Brain Tumor Imaging; Publication info: US2015320890 (A1) 2015-11-12
      11. Polymer Coated Nanoparticles; Publication info: US2015268370 (A1) 2015-09-24
      12. Superparamagnetism nanoparticles, preparation method therefor and applications; Publication info: CN104906600 (A) 2015-09-16
      13. Preparation method and antitumor activity of PEG-modified magnetic graphene oxide (GO); Publication info: CN104815337 (A) 2015-08-05
      14. Phosphor Nanoparticle For Magnetic Resonace Imaging And Magnetic Resonance maging Contrast Containing The Same; Publication info: KR20150066928 (A) 2015-06-17
      15. Preparation method of ferric oxide nanoparticle supported sodium alginate nanogel; Publication info: CN104606687 (A) 2015-05-13
      16. Preparation method and application of polyglutamic acid (PGA)-coated ferric oxide nanoparticles; Publication info: CN104587496 (A) 2015-05-06
      17. Iron Oxide Nanocomposite, Magnetic Resonance Imaging T2 Contrast Medium Comprising Same, And Method For Manufacturing Same; Publication info: US2015079006 (A1) 2015-03-19
      18. Fluorescent magnetic nanoparticle for hypochlorous acid detection and synthetic method thereof; Publication info: CN103952147 (A) 2014-07-30
      19. Gadolinium-doped zinc oxide nanoparticles and preparation method thereof; Publication info: CN103992792 (A) 2014-08-20
      20. Cerium-oxide nanoparticle based device for the detection of reactive oxygen species and monitoring of chronic inflammation; Publication info: US8795733 (B1) 2014-08-05
      21. Cerium oxide nanoparticle-based device for the detection of reactive oxygen species and monitoring of chronic inflammation; Publication info: US8795731 (B1) 2014-08-05
      22. Medical nano composite; Publication info: CN103893783 (A) 2014-07-02
      23. High-Sensitivity Magnetic Resonance Imaging Nano-Contrast Agent Based On An Anionic Polymer And Cationic Polymer Ion Complex, And A Production Method Therefore; Publication info: US2014170077 (A1) 2014-06-19
      24. SPIO-shRNA (superparamagnetic iron oxide-short hair ribonucleic acid) molecular probe with dual actions of MR (magnetic resonance) gene imaging and targeting herapy; Publication info: CN103861127 (A) 2014-06-18
      25. Magnetic Fluid Nanosystem; Publication info: US2014099266 (A1) 2014-04-10
      26. Manganese oxide nanoparticle contrast agent for specifically targeting brain glioma; Publication info: CN103495186 (A) 2014-01-08
      27. Superparamagnetic ferroferric oxide nanoparticle imaging system and method; Publication info: CN103431864 (A) 2013-12-11
      28. Preparation of PEI-coated bimodal contrast agent ferriferrous oxide-gadolinium hydroxide magnetic nanoparticle; Publication info: CN103405792 (A) 2013-11-27
      29. High polymer in-situ modified super-paramagnetic particle, and preparation method and use thereof; Publication info: CN103405790 (A) 2013-11-27
      30. Multifunctional composite nanoparticle and preparation method and application thereof; Publication info: CN103286311 (A) 2013-09-11
      31. Nanoparticle composition and associated method thereof; Publication info: CN103237564 (A) 2013-08-07
      32. NANOVECTORS FOR TARGETED GENE SILENCING AND CYTOTOXIC EFFECT IN CANCER CELLS; Publication info: US2013189367 (A1) 2013-07-25
      33. MAGNETIC RESONANCE IMAGING CONTRAST AGENT COATED WITH ZWITTER ON; Publication info: KR20130045647 (A) 2013-05-06
      34. Synthesis Of High-Performance Iron Oxide Particle Tracers For Magnetic Particle maging (Mpi); Publication Info: Us2013095043 (A1) 2013-04-18
      35. A Nanoparticles Of Surface-Modified With Monosaccharide Phosphate Or Monosaccharide Phosphate Derivatives, Its Colloidal Solution And Use Thereof; Publication info: KR20130015509 (A) 2013-02-14
      36. Drug-loaded nanoparticle with nuclide imaging, fluorescence imaging and MRI unctions, and preparation method and application thereof; Publication info: CN102921022 (A) 2013-02-13
      37. Carbon-coated magnetic nanoparticle gene transfection kit and purposes thereof; Publication info: CN102703510 (A) 2012-10-03
      38. Magnetic fluorescent nanoparticle with biological activity and method for preparing magnetic fluorescent nanoparticle; Publication info: CN102660255 (A) 2012-09-12
      39. Multifunctional magnetic nano-carrier for targeted delivery of microRNA, preparation method and application thereof; Publication info: CN102631687 (A) 2012-08-15
      40. maging Of Biological Tissue Utilizing Nanoparticles; Publication info: US2012164079 (A1) 2012-06-28
      41. Diagnostic Agent Composition And Associated Methods Thereof; Publication info: US2012156142 (A1) 2012-06-21
      42. Nanoparticle Composition And Associated Methods Thereof; Publication info: US2012156141 (A1) 2012-06-21
      43. Preparation method of manganese-zinc ferrite magnetic nanoparticle; Publication info: CN102503390 (A) 2012-06-20
      44. Folic acid-mediated magnetic nanoparticle clusters for combined targeting, diagnosis, and therapy applications; Publication info: TW201113040 (A) 2011-04-16
      45. Novel mixed ligand core/shell iron oxide nanoparticles for inflammation imaging; Publication info: CN102083471 (A) 2011-06-01
      46. Magnetically Responsive Membrane Structures; Publication info: WO2011147926 (A2) 2011-12-01
      47. Gold Nanocages Containing Magnetic Nanoparticles; Publication info: US2010228237 (A1) 2010-09-09
      48. Ultrasmall Superparamagnetic Iron Oxide Nanoparticles And Uses Thereof; Publication info: WO2010093420 (A2) 2010-08-19
      49. Synthesis And Conjugation Of Iron Oxide Nanoparticles To Antibodies For Targeting Specific Cells Using Fluorescence And Mr Imaging Techniques; Publication info: US2010209352 (A1) 2010-08-19
      50. Magnetic Resonance Imaging Contrast Agents Comprising Zinc-Containing Magnetic Metal Oxide Nanoparticles; Publication info: US2010143263 (A1) 2010-06-10
      51. Near Infrared Dye Incorporated Magnetic Core-Silica Shell Multimodal Nanoparticles For Lymphnode And Depp Tissues Optical, Mri And Pet Image; Publication info: KR100939342 (B1) 2010-01-29
      52. MRI T1 Contrasting Agent Comprising Manganese Oxide Nanoparticle; Publication info: KR20090119867 (A) 2009-11-20
      53. Superparamagnetic Nanoparticles Based on Iron Oxides with Modified Surface, Method of Their Preparation and Application; Publication info: US2009309597 (A1) 2009-12-17
      54. Novel Pei-Peg Graft Copolymer Coating Of Iron Oxide Nanoparticles For Inflammation maging; Publication info: US2009280063 (A1) 2009-11-12
      55. Magnetic Resonance Imaging Contrast Agents Containing Water-Soluble Nanoparticles Of Manganese Oxide Or Manganese Metal Oxide; Publication info: US2009220431 (A1) 2009-09-03
      56. Preparation of silicon oxide supported monodisperse nanoparticle nano complex; Publication info: CN101469139 (A) 2009-07-01
      57. In Vivo Imaging and Therapy with Magnetic Nanoparticle Conjugates; Publication info: US2009169478 (A1) 2009-07-02
      58. Stem Cell Targeting Of Cancer, Methods And Compositions Therefore; Publication info: US2009117050 (A1) 2009-05-07
      59. Method for preparation of water-soluble and dispersed iron oxide nanoparticles and application thereof; Publication info: US2008299047 (A1) 2008-12-04
      60. Mri T1 Contrasting Agent Comprising Manganese Oxide Nanoparticle; Publication info: KR20080071472 (A) 2008-08-04
      61. Mri T1 Contrasting Agent Comprising Manganese Oxide Nanoparticle; Publication info: KR20080071463 (A) 2008-08-04
      62. Method for preparation of water-soluble and dispersed iron oxide nanoparticles and application thereof; Publication info: US2005271593 (A1) 2005-12-08
      63. Nanoparticle Conjugated With Cetuximab And Manufacturing Method Thereof; Publication info: KR100830889 (B1) 2008-05-21
      64. Magnetic Nanoparticle Containing Platinum And/Or Gold In Addition To Iron Oxide And Aqueous Colloid Composition Containing The Same; Publication info: JP2008189967 (A) 2008-08-21
      65. Targeted delivery of biologically active substances using iron oxide/gold core-shell nanoparticles; Publication info: GB2415374 (A) 2005-12-28
      66. Magnetic nanoparticles and aqueous colloid composition containing the same; Publication info: EP1952919 (A2) 2008-08-06
    • Publications authored by partners
      Application of Europium-Doped Very Small Iron Oxide Nanoparticles to Visualize Neuroinflammation with MRI and Fluorescence Microscopy.
      Millward JM, Ariza de Schellenberger A, Berndt D, Hanke-Vela L, Schellenberger E, Waiczies S, Taupitz M, Kobayashi Y, Wagner S, Infante-Duarte C.
      Neuroscience. 2017 Dec 19. pii: S0306-4522(17)30886-2.
      doi: 10.1016/j.neuroscience.2017.12.014.
      https://www.ncbi.nlm.nih.gov/pubmed/29273325

      Synthesis of europium-doped VSOP, customized enhancer solution and improved microscopy fluorescence methodology for unambiguous histological detection.
      de Schellenberger AA, Hauptmann R, Millward JM, Schellenberger E, Kobayashi Y, Taupitz M, Infante-Duarte C, Schnorr J, Wagner S.
      J Nanobiotechnology. 2017 Oct 10;15(1):71.
      doi: 10.1186/s12951-017-0301-6.
      https://www.ncbi.nlm.nih.gov/pubmed/29017510
      Inflammation-induced brain endothelial activation leads to uptake of electrostatically stabilized iron oxide nanoparticles via sulfated glycosaminoglycans.
      Berndt D, Millward JM, Schnorr J, Taupitz M, Stangl V, Paul F, Wagner S, Wuerfel JT, Sack I, Ludwig A, Infante-Duarte C.
      Nanomedicine. 2017 May;13(4):1411-1421. Epub 2017 Jan 25.
      doi: 10.1016/j.nano.2017.01.010.
      https://www.ncbi.nlm.nih.gov/pubmed/28131884

      Europium doping of superparamagnetic iron oxide nanoparticles enables their detection by fluorescence microscopy and for quantitative analytics.
      Kobayashi Y, Hauptmann R, Kratz H, Ebert M, Wagner S, Taupitz M.
      Technol Health Care. 2017;25(3):457-470.
      doi: 10.3233/THC-161285.
      https://www.ncbi.nlm.nih.gov/pubmed/27935574

      Magnetic Particle Spectroscopy Reveals Dynamic Changes in the Magnetic Behavior of Very Small Superparamagnetic Iron Oxide Nanoparticles During Cellular Uptake and Enables Determination of Cell-Labeling Efficacy.
      Poller WC, Löwa N, Wiekhorst F, Taupitz M, Wagner S, Möller K, Baumann G, Stangl V, Trahms L, Ludwig A.
      J Biomed Nanotechnol. 2016 Feb;12(2):337-46.
      https://www.ncbi.nlm.nih.gov/pubmed/27305767

      Labeling of mesenchymal stem cells for MRI with single-cell sensitivity.
      Ariza de Schellenberger A, Kratz H, Farr TD, Löwa N, Hauptmann R, Wagner S, Taupitz M, Schnorr J, Schellenberger EA.
      Int J Nanomedicine. 2016 Apr 12;11:1517-35. eCollection 2016.
      doi: 10.2147/IJN.S101141.
      https://www.ncbi.nlm.nih.gov/pubmed/27110112

      LA-ICP-MS Allows Quantitative Microscopy of Europium-Doped Iron Oxide Nanoparticles and is a Possible Alternative to Ambiguous Prussian Blue Iron Staining.
      Scharlach C, Müller L, Wagner S, Kobayashi Y, Kratz H, Ebert M, Jakubowski N, Schellenberger E.
      J Biomed Nanotechnol. 2016 May;12(5):1001-10.
      https://www.ncbi.nlm.nih.gov/pubmed/27305821

      Biocompatibility of very small superparamagnetic iron oxide nanoparticles in murine organotypic hippocampal slice cultures and the role of microglia.
      Pohland M, Glumm R, Wiekhorst F, Kiwit J, Glumm J.
      Int J Nanomedicine. 2017 Feb 27;12:1577-1591. eCollection 2017
      doi: 10.2147/IJN.S127206.
      https://www.ncbi.nlm.nih.gov/pubmed/28280327

      Synthesis of acid-stabilized iron oxide nanoparticles and comparison for targeting atherosclerotic plaques: evaluation by MRI, quantitative MPS, and TEM alternative to ambiguous Prussian blue iron staining.
      Scharlach C, Kratz H, Wiekhorst F, Warmuth C, Schnorr J, Genter G, Ebert M, Mueller S, Schellenberger E.
      Nanomedicine. 2015 Jul;11(5):1085-95. Epub 2015 Feb 4.
      doi: 10.1016/j.nano.2015.01.002.
      https://www.ncbi.nlm.nih.gov/pubmed/25659644